Familial colorectal cancer, omics and all that jazz...

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Familial colorectal cancer, omics and all that jazz...

Type: Doctoral Thesis
Title: Familial colorectal cancer, omics and all that jazz...
Author: Mendes Cardoso Vaz, Joana Rita
Publisher: Center for Human and Clinical Genetics, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2007-02-14
Keywords: Adenomas
Expression profiling
Data integration
Genomic profiling
Hereditary colorectal cancer
Abstract: Notwithstanding the hereditary colorectal cancer (CRC) syndromes where the underlying genetic defects have been characterized, for the vast majority of familial cases (15-20%) the disease-causing genes remain unknown, posing serious problems for genetic counselling and patient management of individuals at risk. Aiming to improve the molecular classification of familial CRC, an omics-based approach employing BAC (aCGH), cDNA microarrays and distinct in silico analytical strategies were used to study both the genomic and expression profiles generated from a large collection of colorectal adenomatous polyps. Though the overall results showed a high degree of similarity shared by genomic and expression profiles of familial colonic adenomas, which casts several serious doubts on the classification of hereditary CRC syndromes by omics technologies, the presented findings also argue in favour of a common molecular basis for CRC formation and contribute to the elucidation of the early events associated with colorectal tumorigenesis, namely the early occurrence of CIN and of the complex cross-talk between signalling pathways, in hereditary and in sporadic CRC and even across-species, and additionally in highlighting the power of integrated approaches in the discovery and prioritization of putative targets involved in colorectal tumorigenesis.
Description: Promotoren: R. Fodde, J. Morreau, Co-promotor: J. Boer
With summary in Dutch
Faculty: LUMC
Citation: Cardoso, J., 2007, Doctoral thesis, Leiden University
ISBN: 9090215069
Sponsor: KWF (Dutch Cancer Society)
Handle: http://hdl.handle.net/1887/9922

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