HIV and Schistosoma spp. interactions: epidemiology and consequences for detection and prevention in the lake region of Tanzania

Leiden Repository

HIV and Schistosoma spp. interactions: epidemiology and consequences for detection and prevention in the lake region of Tanzania

Type: Doctoral Thesis
Title: HIV and Schistosoma spp. interactions: epidemiology and consequences for detection and prevention in the lake region of Tanzania
Author: Colombe, S.
Issue Date: 2020-01-07
Keywords: Schistosoma spp
HIV
AIDS
Co-infection
ART
serodiscordant
Tanzania
Viral load
microscopy
Circulating Anodic Antigen
Abstract: An estimated 6 million individuals are co-infected with HIV and schistosomiasis. This thesis seeks to add to the comprehension of the epidemiology of HIV and schistosome co-infections in Tanzania, by Lake Victoria. It first evaluates Tanzania’s progress regarding HIV care and defines the study population and the challenges it faces in the fight against co-infections. It then explores the impact of Schistosoma infection on HIV outcomes and transmission. One of the main findings is that people who were infected with Schistosoma when they also acquired HIV infection, on average survive longer and have slower decline in CD4 counts than those who were not infected with Schistosoma in the first place. This thesis also shows that individuals with HIV and Schistosoma spp. co-infections have lower viral loads than those with HIV alone, when accounting for time infected with HIV, and estimates the first hazard rate of HIV transmission from co-infected partners. Finally, this thesis explores the impact of HIV infection on the detection of Schistosoma in co-infected people and concludes that co-infected individuals and women are less likely to excrete parasite eggs. Both local and systemic interactions are discussed in light of those results.
Promotor: Supervisor: Yazdanbakhsh M. Co-Supervisor: Corstjens P.L.A.M., Downs J.A.
Faculty: Leiden University of Medical Center [LUMC]
University: Leiden University
Handle: http://hdl.handle.net/1887/82478
 

Files in this item

Description Size View
application/pdf Full text 6.371Mb View/Open
application/pdf Cover 909.5Kb View/Open
application/pdf Title pages_Contents_Abbreviations 1.003Mb View/Open
application/pdf Chapter 1 1.624Mb View/Open
application/pdf Chapter 2 1.553Mb View/Open Full text at publisher site
application/pdf Chapter 3 1.440Mb View/Open Full text at publisher site
application/pdf Chapter 4 1.253Mb View/Open Full text at publisher site
application/pdf Chapter 5 2.114Mb View/Open Full text at publisher site
application/pdf Chapter 6 966.8Kb View/Open Full text at publisher site
application/pdf Chapter 7 1.476Mb View/Open
application/pdf Summary in English 615.8Kb View/Open
application/pdf Summary in Dutch 422.6Kb View/Open
application/pdf Acknowledgement ... Vitae_List of publications 620.4Kb View/Open
application/pdf Propositions 258.4Kb View/Open

This item appears in the following Collection(s)