The role of zebrafish larvae for studying anxiety-like behaviour

Leiden Repository

The role of zebrafish larvae for studying anxiety-like behaviour

Type: Doctoral Thesis
Title: The role of zebrafish larvae for studying anxiety-like behaviour
Author: Muniandy, Y.
Issue Date: 2019-11-21
Keywords: Zebrafish larvae
Anxiety disorders
Developmental toxicity
Behavioural assay
Herbal anxiolytics
Abstract: The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs. Several behavioural parameters of larval zebrafish were used to evaluate anxiety-like behaviours, which are locomotion, startle response, and thigmotaxis. In addition to this, behavioural assays are also used to screen synthetic anxiolytics commonly used in the treatment of anxiety disorders. Finally, the toxic effects of the synthetic and herbal-based anxiolytics were also assessed on the developing zebrafish larvae.
Promotor: Supervisor: Richardson M.K. Co-Supervisor: Choi Y.H.
Faculty: Science
University: Leiden
Handle: http://hdl.handle.net/1887/80415
 

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application/pdf Full Text 15.26Mb Under embargo until 2021-05-21
application/pdf Cover 2.027Mb View/Open
application/pdf Title Page_Contents 327.9Kb View/Open
application/pdf Chapter 01 275.4Kb View/Open
application/pdf Chapter 02 641.4Kb View/Open Full text at publisher site
application/pdf Chapter 03 3.840Mb Under embargo until 2021-05-21
application/pdf Chapter 04 4.928Mb Under embargo until 2021-05-21
application/pdf Chapter 05 5.455Mb Under embargo until 2021-05-21
application/pdf Chapter 06_Summary 359.8Kb View/Open
application/pdf Summary_in Dutch 449.8Kb View/Open
application/pdf Acknowledgements_CV_Publications 204.4Kb View/Open
application/pdf Propositions 111.0Kb View/Open

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