On the geometry of demixing: A study of lipid phase separation on curved surfaces

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On the geometry of demixing: A study of lipid phase separation on curved surfaces

Type: Doctoral Thesis
Title: On the geometry of demixing: A study of lipid phase separation on curved surfaces
Author: Rinaldin, M.
Journal Title: Casimir PhD Series
Issue Date: 2019-11-07
Keywords: curvature
lipid membrane
bilayer
phase separation
mechanics
Abstract: Like a mixture of oil and water, lipid membranes separate into two liquid phases. While it is known that on a flat surface coexisting liquid phases result in the formation of circular domains, little is known about liquid-liquid phase separation on curved surfaces. In this thesis, a collection of experimental tools are offered to unravel this problem. Novel model systems in vitro consisting of supported lipid bilayers, or bilayers stabilised on solid substrates, are developed by using colloidal particles and micro-printed structures. In this way, both the composition and the geometry of the membrane can be controlled allowing for a direct comparison with simulation and theory.
Promotor: Supervisor: Kraft D.J., Hecke M.L. van Co-Supervisor: Giomi L.
Faculty: Faculty of Science
University: Leiden University
Uri: urn:isbn:9789085934158
Handle: http://hdl.handle.net/1887/80202
 

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application/pdf Title pages_Contents 91.93Kb View/Open
application/pdf Chapter 1 75.76Mb View/Open
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application/pdf Chapter 3 74.03Mb Under embargo until 2021-05-07
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application/pdf Appendix_Bibliography 5.692Mb View/Open
application/pdf Summary in Dutch 104.6Kb View/Open
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application/pdf List of publica ... lum Vitae_Acknowledgements 105.5Kb View/Open
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