Hitting the right nerve: effects of transcutaneous vagus nerve stimulation on symptoms of anxiety

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Hitting the right nerve: effects of transcutaneous vagus nerve stimulation on symptoms of anxiety

Type: Doctoral Thesis
Title: Hitting the right nerve: effects of transcutaneous vagus nerve stimulation on symptoms of anxiety
Author: Burger, A.M.
Issue Date: 2019-05-15
Keywords: Vagus Nerve Stimulation
anxiety
learning
fear conditioning
noradrenaline
Abstract: he overarching goal of this dissertation was to assess whether transcutaneous vagus nerve stimulation (tVNS) has beneficial effects over sham stimulation in laboratory models of anxiety. Specifically, in Part I, the effects of tVNS were tested in a fear conditioning paradigm to test the utility of tVNS as an add-on treatment for exposure therapy. In Part II, the effects of tVNS as a stand-alone treatment for one of the core symptoms of anxiety – perseverative cognition – was tested within the experimental framework of a Breathing Focus task. Part III deals with working mechanisms: what is the optimal site of the ear to stimulate the auricular branch of the vagus nerve (ABVN) and what is the hypothesized working mechanism underlying the anxiolytic effects of tVNS? Specifically, the effects of tVNS on both physiological as well as behavioral indices of locus coeruleus – noradrenaline (LC-NA) network activity were tested.
Promotor: Supervisor: Does W. van der, Brosschot J.F. Co-Supervisor: Verkuil B.
Faculty: Faculty of Social and Behavioural Sciences
University: Leiden University
Handle: http://hdl.handle.net/1887/72624
 

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application/pdf Full text 3.169Mb Under embargo until 2020-11-15
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application/pdf Title pages_Contents 753.6Kb View/Open
application/pdf Chapter 1 738.1Kb View/Open
application/pdf Part I : Chapter 2 804.6Kb View/Open Full text at publisher site
application/pdf Part I : Chapter 3 1.115Mb Under embargo until 2019-07-08 Full text at publisher site
application/pdf Part I : Chapter 4 986.0Kb View/Open Full text at publisher site
application/pdf Part I : Chapter 5 865.2Kb Under embargo until 2020-04-29 Full text at publisher site
application/pdf Part II : Chapter 6 972.1Kb Under embargo until 2020-03-20 Full text at publisher site
application/pdf Part III : Chapter 7 764.9Kb View/Open
application/pdf Part III : Chapter 8 1.134Mb Under embargo until 2020-11-15
application/pdf Part III : Chapter 9 725.2Kb View/Open
application/pdf Summary in Dutch 673.6Kb View/Open
application/pdf Curriculum Vitae_references_Acknowledgements 633.9Kb View/Open
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