Characterizing iron-oxide nanoparticles in the human brain

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Characterizing iron-oxide nanoparticles in the human brain

Type: Master thesis
Title: Characterizing iron-oxide nanoparticles in the human brain
Author: Boers, Laurens
Issue Date: 2018-11-16
Keywords: SQUID
MRI
ORS-FISP
Human brain
C. Elegans
magnetite
ferritin
Quantitative Susceptibility Mapping
Isothermal Remanent Magnetization
Abstract: In this study, we employed several methods to characterize iron-oxide nanoparticles using SQUID magnetometry and MRI. With SQUID magnetometry, we measured the Isothermal Remanent Magnetization of C. Elegans and two human brain samples. We obtained the iron concentration from the fit. We were able to detect changes in iron concentration due to mutations in C. Elegans. For the MRI measurements, we used Quantitative Susceptibility Mapping and an Off-Resonance Saturation method for brain phantoms. These phantoms consist of different concentrations of magnetite or ferritin dissolved in an agarose gel and mimics the human brain. With QSM we observed a comparable slope of the susceptibility/µg iron/ml. For the ORS method, a good agreement is found between the obtained iron concentration and the pre-determined iron concentration in the sample.
Supervisor: Bossoni, Lucia
Faculty: Faculty of Science
Department: Physics (Master)
Specialisation: Physics, Quantum Matter and Optics
ECTS Credits: 3
Evaluation: 7
Handle: http://hdl.handle.net/1887/72503
 

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