Cholesterol metabolism and hematopoiesis interaction in atherothrombosis

Leiden Repository

Cholesterol metabolism and hematopoiesis interaction in atherothrombosis

Type: Doctoral Thesis
Title: Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Author: Ouweneel, A.B.
Issue Date: 2019-03-21
Keywords: Atherosclerosis
Atherothrombosis
Hematopoiesis
Megakaryopoiesis
Hypercholesterolemia
Cholesterol efflux
High_density lipoproteins
Mouse models
Small interfering RNA
Protein C
Abstract: Cardiovascular disease is the leading cause of death worldwide. The primary underlying pathology of cardiovascular disease is atherosclerosis. Atherosclerosis is a chronic, multifactorial disease in which lipid accumulates in the arterial wall, leading to a local inflammatory reaction and atherosclerotic plaque formation. Atherosclerotic disease develops largely asymptomatic over a lifetime. However, plaque rupture or erosion can cause the formation of a superimposed thrombus, blocking the flow of blood, and cause acute cardiovascular events such as myocardial infarction or ischemic stroke. Defects in cholesterol metabolism and hypercholesterolemia, which are major risk factors for atherosclerosis, have been shown to affect hematopoiesis, immune cell production and platelet counts and reactivity. Therefore, bone marrow cholesterol handling is an interesting target in the battle against cardiovascular disease, and acute cardiovascular events in particular. This thesis describes novel interactions between cholesterol metabolism and the production of immune cells and platelets, and its effects on atherosclerosis and atherothrombosis development.
Promotor: Supervisor: Eck M. van Co-Supervisor: Vlijmen B.J.M. van
Faculty: Faculty of Science
University: Leiden University
Uri: urn:isbn:9789463612340
Handle: http://hdl.handle.net/1887/70039
 

Files in this item

Description Size View
application/pdf Full Text 46.01Mb Under embargo until 2020-09-21
application/pdf Cover 14.09Mb View/Open
application/pdf Title Pages_Contents 80.55Kb View/Open
application/pdf Chapter 1 8.419Mb View/Open
application/pdf Chapter 2 8.469Mb View/Open Full text at publisher site
application/pdf Chapter 3 9.310Mb View/Open Full text at publisher site
application/pdf Chapter 4 8.423Mb Under embargo until 2020-09-21
application/pdf Chapter 5 9.219Mb Under embargo until 2020-09-21
application/pdf Chapter 6 8.324Mb View/Open
application/pdf Chapter 7 23.77Mb View/Open Full text at publisher site
application/pdf Chapter 8 27.30Mb View/Open Full text at publisher site
application/pdf Chapter 9 8.304Mb Under embargo until 2020-09-21
application/pdf Chapter 10 8.433Mb View/Open
application/pdf Summary in Dutch 8.301Mb View/Open
application/pdf Bibliography_Curriculum Vitae 8.301Mb View/Open
application/pdf Propositions 479.1Kb View/Open

This item appears in the following Collection(s)