Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia

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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia

Type: Doctoral Thesis
Title: Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
Author: Grimm, S.H.
Issue Date: 2019-02-20
Keywords: Kinase
FLT3
Kinase inhibitor
Small molecule inhibitors
Acute myeloid leukemia
Drug discovery
Chemical proteomics
Abstract: The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates. Fms-like tyrosine kinase 3 (FLT3) receptor mutations have been identified as a driver mutation in cancer progression in a subgroup of AML patients. Clinical trials have shown emergence of drug resistant mutants, emphasizing the ongoing need for new chemical matter to enable the treatment of this disease. This thesis describes the discovery and evaluation of new chemical series of FLT3 inhibitors and furthermore employs label-free chemical proteomics techniques to evaluate new and existing FLT3 inhibitors for their cellular kinase off-target profile.
Promotor: Supervisor: Stelt M. van der, Neefjes J.
Faculty: Faculty of Science
University: Leiden University
Handle: http://hdl.handle.net/1887/68880
 

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