Obesity and Cardiovascular disease. Results from the Netherlands Epidemiology of Obesity Study

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Obesity and Cardiovascular disease. Results from the Netherlands Epidemiology of Obesity Study

Type: Doctoral Thesis
Title: Obesity and Cardiovascular disease. Results from the Netherlands Epidemiology of Obesity Study
Author: Elffers, T.W.
Issue Date: 2019-01-09
Keywords: Obesity
Adipose tissue
Electrocardiography
Atherosclerosis
Epidemiology
Abstract: In this thesis, the importance of visceral obesity in the relation of obesity with cardiometabolic risk factors (chapter 2) was confirmed and it was shown that in individuals free of known cardiovascular disease clustering of cardiometabolic risk factors is associated with changes in electrocardiographic parameters indicative of subclinical cardiovascular disease (chapter 3). The findings from chapter 3 also point to the importance of the prevention of these metabolic syndrome components, not only in obese, but also in non-obese individuals. Furthermore, both overall and abdominal adiposity were found to be associated with these deleterious changes in electrocardiographic parameters (chapter 4). Borderline Q-waves were associated with a negative cardiovascular risk profile and increased pulse wave velocity and intima-media thickness (chapter 5). Chapter 6 shows that several cardiovascular risk factors were associated with a wider spatial QRS-T angle, which reflects ventricular electrophysiological heterogeneity. Both carotid intima-media thickness, as measure of subclinical atherosclerosis, and pulse wave velocity, as measure of arterial stiffness, were associated with a wider spatial QRS-T angle. In chapter 7, improvement of electrocardiographic detection of left ventricular hypertrophy with conventional electrocardiographic criteria by taking into account body mass index and the spatial QRS-T angle is shown.
Promotor: Supervisor: Jukema J.W., Rosendaal F.R. Co-Supervisor: Trompet S.
Faculty: Medicine / Leiden University Medical Center (LUMC)
University: Leiden
Uri: urn:isbn:9789463801713
Handle: http://hdl.handle.net/1887/67913
 

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application/pdf Full Text 4.160Mb Under embargo until 2020-01-09
application/pdf Cover 663.2Kb View/Open
application/pdf Title Page_Contents 818.3Kb View/Open
application/pdf Chapter 01 1.447Mb View/Open
application/pdf Chapter 02 1.104Mb View/Open Full text at publisher site
application/pdf Chapter 03 1.195Mb View/Open Full text at publisher site
application/pdf Chapter 04 1.616Mb View/Open Full text at publisher site
application/pdf Chapter 05 1.170Mb View/Open Full text at publisher site
application/pdf Chapter 06 1.086Mb Under embargo until 2020-01-09
application/pdf Chapter 07 1.202Mb Under embargo until 2020-01-09
application/pdf Chapter 08 822.6Kb View/Open
application/pdf Summary_in Dutch 847.1Kb View/Open
application/pdf Acknowledgements_CV_Publications 1.022Mb View/Open
application/pdf Propositions 161.5Kb View/Open

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