2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain

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2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain

Type: Article / Letter to editor
Title: 2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain
Author: Baggelaar, M.P.Maccarrone, M.Stelt, M. van der
Journal Title: Progress in Lipid Research
Volume: 71
Start Page: 1
End Page: 17
Pages: 17
Issue Date: 2018
Abstract: 2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB1 receptor. It is involved in a wide array of (patho)physiological functions, such as emotion, cognition, energy balance, pain sensation and neuroinflammation. In this review, we describe the biosynthetic and metabolic pathways of 2-AG and how chemical and genetic perturbation of these pathways has led to insight in the biological role of this signaling lipid. Finally, we discuss the potential therapeutic benefits of modulating 2-AG levels in the brain.
Uri: https://www.sciencedirect.com/science/article/pii/S0163782717300619?via=ihub
Handle: http://hdl.handle.net/1887/67627
 

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