Cellular models for fundamental and applied biomedical research

Leiden Repository

Cellular models for fundamental and applied biomedical research

Type: Doctoral Thesis
Title: Cellular models for fundamental and applied biomedical research
Author: Liu, J.
Issue Date: 2018-11-28
Keywords: Senescence
Lentivirus
Cell fusion
Immortalization
Cardiomyocyte
Brown preadipocyte
hERG channel
Abstract: Cell culture models play an important role in biomedical research and will continue to do so given the growing opposition to vivisection and the limited predictive value of animal models for human disease. Moreover, cell culture models can be easily established to mimic physiological or pathological processes, which is difficult to accomplish using in silico models. While non-cellular in vitro models are highly suitable for studying simple biochemical processes, cell culture models recapitulate many of the complex regulatory circuits governing protein activity in vivo and hence allow investigation of diverse physiological processes. Also, cell culture models offer the possibility to address fundamental research questions in a much more simplified, specific and controllable manner than can be achieved using in vivo models.
Promotor: Supervisor: Schalij M.J. Co-Supervisor: Vries A.A.F. de, Pijnappels D.A.
Faculty: Faculty of Medicine, Leiden University Medical Center (LUMC)
University: Leiden University
Uri: urn:isbn:9789463751612
Handle: http://hdl.handle.net/1887/67296
 

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