Preclinical validation of putative targets in cardiovascular and metabolic disease

Leiden Repository

Preclinical validation of putative targets in cardiovascular and metabolic disease

Type: Doctoral Thesis
Title: Preclinical validation of putative targets in cardiovascular and metabolic disease
Author: Nahon, J.E.
Issue Date: 2018-11-15
Keywords: Atherosclerosis
Bone marrow transplantation
Hepatic steatosis
Type 2 diabetes
Obesity
Abstract: Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood. Other risk factors contributing to cardiovascular disease can develop in individuals which are overweight. The clinical consequences of being overweight are clustered in the medical term: metabolic syndrome. Included in the metabolic syndrome are high blood pressure, dyslipidemia and glucose intolerance. At present, most cardiovascular disease patients are treated with statins which lower blood cholesterol levels. However, this treatment is not as effective in all patients and can cause some adverse drug reactions. Therefore, it is essential that novel therapeutic targets for the treatment of cardiovascular disease are identified. In this thesis, potential novel therapeutic targets in cardiovascular disease and metabolic syndrome are validated. In total, three potential targets were investigated: proteoglycan 4, protein arginine methyltransferase 3 and stabilin 1. Our studies showed the involvement of two of these targets in the development of cardiovascular disease and metabolic syndrome. Moreover, our results stress (1) that cardiovascular disease and metabolic syndrome are complex, multifactorial diseases with overlapping mechanisms and (2) that integration of research into both diseases can benefit therapeutic target identification and validation. 
Promotor: Supervisor: Eck M. van, Hoekstra M.
Faculty: Faculty of Science
University: Leiden University
Uri: urn:isbn:9789463611572
Handle: http://hdl.handle.net/1887/66799
 

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