Novel formulations and delivery strategies for inactivated polio vaccines : new routes with benefits

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Novel formulations and delivery strategies for inactivated polio vaccines : new routes with benefits

Type: Doctoral Thesis
Title: Novel formulations and delivery strategies for inactivated polio vaccines : new routes with benefits
Author: Kraan, H.B.
Issue Date: 2018-10-18
Keywords: Vaccines
Polio
Alternative delivery
Needle-free
Mucosal
Sublingual
Oral films
Bioneedle
Lyophilization
Inactivated polio vaccine
Abstract: This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination. A new generation of IPV should not only be affordable and safe to produce, but preferably should also induce mucosal immunity, remain stable at unrefrigerated conditions, and be easy to administer. This is also important with regard to stockpiling and outbreak management in the period towards and beyond polio eradication. Solid dosage forms that have improved thermostability, like biodegradable Bioneedles comprising lyophilized IPV or polymer-based oral films, would be favorable to reach remote areas in developing countries for which proper logistics are not available. Replacing the currently used polio vaccines with a thermostable vaccine may yield significant cost savings. Furthermore, vaccination via mucosal routes showed to have important advantages over conventional intramuscular vaccination using needle and syringes.
Promotor: Supervisor: Kersten G.F.A., Frijlink H.W. Co-Supervisor: Amorij J.-P.
Faculty: Faculty of Science
University: Leiden University
Uri: urn:isbn:9789493014749
Handle: http://hdl.handle.net/1887/66318
 

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