Design and application of dextran based cross-linked networks

Leiden Repository

Design and application of dextran based cross-linked networks

Type: Doctoral Thesis
Title: Design and application of dextran based cross-linked networks
Author: Gao, Y.
Issue Date: 2018-10-18
Keywords: Dextran
Cross-linked network
Hydrogels
Human serum albumin
Drug delivery
Giant unilamellar vesicles
Swelling
Abstract: This thesis describes the design, characterization and application of dextran based crosslinked network. Dextran, a neutral and hydrophilic polysaccharide, was functionalized with maleimide or vinyl sulfone groups which are able to form covalent bonds with nucleophilic thiols via a thiol-Michael addition reaction. The functionalized dextran polymers are liable to be crosslinked to generate 3D networks. Novel drug delivery platforms, including dextran-albumin hydrogels and dextran-poly(ethylene glycol)-albumin hydrogels, were established in which human serum albumin acts simultaneously as an affinity-based drug carrier and crosslinker. The obtained drug delivery platforms showed high drug loading efficiency and demonstrated sustained release of drug molecules. This thesis also explores emerging applications of hydrogels. New method to form giant unilamellar vesicles was established by assisting the hydration process of a lipid film with a dextran-poly(ethylene glycol) hydrogel film. Using this approach, polymer and additive-free GUVs can be prepared rapidly in high yield under physiological ionic strength conditions.
Promotor: Supervisor: Kros A. Co-Supervisor: Kieltyka R.
Faculty: Faculty of Science
University: Leiden University
Handle: http://hdl.handle.net/1887/66265
 

Files in this item

Description Size View
application/pdf Full Text 4.991Mb Under embargo until 2020-04-18
application/pdf Cover 8.087Mb View/Open
application/pdf Title Pages_Contents 132.2Kb View/Open
application/pdf Chapter 1 315.3Kb View/Open
application/pdf Chapter 2 726.3Kb View/Open Full text at publisher site
application/pdf Chapter 3 1.004Mb View/Open Full text at publisher site
application/pdf Chapter 4 908.6Kb Under embargo until 2020-04-18
application/pdf Chapter 5 1.426Mb View/Open Full text at publisher site
application/pdf Chapter 6 1.656Mb Under embargo until 2020-04-18
application/pdf Chapter 7 194.0Kb View/Open
application/pdf Summary in Dutch 194.9Kb View/Open
application/pdf Abbreviations_Curriculum Vitae_Publications 194.1Kb View/Open
application/pdf Propositions 125.8Kb View/Open

This item appears in the following Collection(s)