Fusion of X-ray angiography and optical coherence tomography for coronary flow simulation

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Fusion of X-ray angiography and optical coherence tomography for coronary flow simulation

Type: Doctoral Thesis
Title: Fusion of X-ray angiography and optical coherence tomography for coronary flow simulation
Author: Li, Y.
Journal Title: ASCI dissertation series
Issue Date: 2018-10-09
Keywords: 3D reconstruction
Angiography
Optical Coherence Tomography
Bioresorbable Stents
Computational fluid dynamics
Shear stress
Fractional flow reserve
Abstract: In conclusion, this thesis proposes a new approach for reconstruction of coronary artery and the implanted BRS by fusion of OCT and X-ray angiography to analyze intracoronary ESS in vivo. The studies conducted in this thesis demonstrate the feasibility of the proposed approach to analyze the detailed local coronary hemodynamics in patients, including the SS patterns after BRS implantation in coronary bifurcations. We observed that in vivo assessment of ESS was closely related to: (1) reconstruction of the side branches; (2) reconstruction of the BRS; (3) patient-specific flow; (4) post-processing portion size in which ESS was calculated. Based on these findings, we propose the following standard analysis procedures for assessment of intracoronary ESS in vivo: (1) reconstruct both the main vessel and its side branches to create a more accurate geometric model. (2) reconstruct BRS in naturally-bent shape and include it in the CFD analysis for assessment of ESS after BRS implantation; (3) use patient-specific coronary flow in the CFD analysis to have more accurate boundary condition; (4) set the proportion size according to the interrogated region of interest for quantification of the ESS in portions.
Promotor: Supervisor: Reiber J.H.C., Lelieveldt B.P.F. Co-Supervisor: Tu S.
Faculty: Faculty of Medicine, Leiden University Medical Center (LUMC)
University: Leiden University
Uri: urn:isbn:9789463751131
Handle: http://hdl.handle.net/1887/66128
 

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