SDHD-related head and neck paragangliomas & their natural course

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SDHD-related head and neck paragangliomas & their natural course

Type: Doctoral Thesis
Title: SDHD-related head and neck paragangliomas & their natural course
Author: Heesterman, B.L.
Issue Date: 2018-09-13
Keywords: SDHD mutation
Paragangliomas
Carotid body tumors
Vagal body tumors
Tumor volume
Growth
Prediction
Mathematical models
Clinical progression
Mortality
Abstract: SDHD-related head and neck paragangliomas are, hereditary and generally benign, neuroendocrine tumors that arise from paraganglionic tissue associated with the parasympathetic nervous system. The primary aim of this thesis was to gain more insight in the natural course of SDHD-related head and neck paragangliomas and ultimately improve surveillance and treatment strategies, as well as counseling of both patients and their family members. The risk of occult and metachronous paragangliomas, tumor growth, clinical progression and survival of SDHD germline mutation carriers were addressed.
Promotor: Supervisor: Benthem P.P.G. van Co-Supervisor: Jansen J.C., Verbist B.M.
Faculty: Faculty of Medicine, Leiden Uiversity Medical Center (LUMC)
University: Leiden University
Handle: http://hdl.handle.net/1887/65453
 

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