||Zika virus (ZIKAV) infection has recently become a public health concern, as well as an enduring scientific, and technological (S&T) challenge for researchers worldwide. Especially in Latin America and Caribbean (LAC) countries, greatly affected by the outbreak, understanding the S&T response is essential to guide future research and to direct financial investments. In the present study, we focused on ZIKAV epidemics using combined publication (from international and regional databases: Web of Science, Scopus, PubMed, SciELO and LILACS), patent (Orbit Intelligence) and social network analysis (co-authorship) to contribute to the discussion of the role of S&T knowledge produced and disseminated regionally to address global challenges. International databases searches retrieved 5,831 documents, evidencing a dramatic increase in scientific publications targeting ZIKAV from 2015 onwards. Overall, only 32% of the 282 unique documents indexed in SciELO and LILACS, were retrieved in the international databases. United States, France, and Brazil were the top three most central countries of the global network for ZIKAV research. In addition, United States was shown to be the most frequent collaborator of LAC countries. Patent search retrieved 311 patent families. So far, only four are from LAC organizations, all based in Brazil. Our analysis offered a comprehensive representation of ZIKAV’s research and development and showed that scientific efforts from LAC countries, in particular from Brazil, had a significant role in the generation of global knowledge. The study highlights the need for a continued interdisciplinary approach in order to improve our ability to prepare for, control and prevent future outbreaks.