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Canonical and non-canonical Wnt signaling in hematopoiesis and lymphocyte development
The immune system of mammals is responsible for protecting our body against pathogens
and foreign substances (antigens), and it consists of two discrete lines of defense. The first
line called innate immunity and provide a quick and nonspecific defense. The innate immunity
includes different cells types, such as mast cells, macrophages, neutrophils, eosinophils,
dendritic cells and natural killer (NK) cells. The second line of defense called adaptive immunity
responds in an antigen-specific manner, and comprised of B and T lymphocyte cells.
This thesis focuses on one of the signals which are known to play an important role during
HSC repopulation and T cell development that is Wnt signaling pathway. Depending
on the tissue/cell types (microenvironment) and specific class of Wnt proteins binding to
the corresponding receptors on the developing lymphocytes, two discrete downstream
pathways will be activated namely...
Show moreThe immune system of mammals is responsible for protecting our body against pathogens
and foreign substances (antigens), and it consists of two discrete lines of defense. The first
line called innate immunity and provide a quick and nonspecific defense. The innate immunity
includes different cells types, such as mast cells, macrophages, neutrophils, eosinophils,
dendritic cells and natural killer (NK) cells. The second line of defense called adaptive immunity
responds in an antigen-specific manner, and comprised of B and T lymphocyte cells.
This thesis focuses on one of the signals which are known to play an important role during
HSC repopulation and T cell development that is Wnt signaling pathway. Depending
on the tissue/cell types (microenvironment) and specific class of Wnt proteins binding to
the corresponding receptors on the developing lymphocytes, two discrete downstream
pathways will be activated namely canonical or non-canonical Wnt pathway. The main aim
of this thesis is to dissect the roles of these two distinct pathways during hematopoiesis
and lymphocyte development in murine as a physiologically relevant animal model.
Show less- All authors
- Famili, F.
- Supervisor
- Staal, F.J.T.
- Committee
- Koning, F.; Noordermeer, J.N.; Meijerink, J.P.P.; Zwaginga, J.J.
- Qualification
- Doctor (dr.)
- Awarding Institution
- immunohematology and bloodtransfusion , Medicine / Leiden University Medical Center (LUMC) , Leiden University
- Date
- 2018-05-30
- ISBN
- 9789462959200