Advancing forensic RNA profiling

Leiden Repository

Advancing forensic RNA profiling

Type: Doctoral Thesis
Title: Advancing forensic RNA profiling
Author: Berge, M.W. van den
Issue Date: 2018-06-28
Keywords: Messenger RNA (mRNA) profiling
Cell type identification
Body fluid identification
Organ tissue identification
Forensic science
Abstract: In forensic science, next to the question of who contributed to the trace (DNA analysis), knowledge regarding the cellular origin of the evidentiary trace, thus what cell type contributed to the trace, is often key to facilitate inference of activities. To this aid, RNA-based approaches have shown their up come in forensic investigations since 1999. RNA profiling techniques rely on the fact that different cell types, such as blood, express a characteristic pattern of genes, such as haemoglobin beta (HBB) expressed in the red blood cells. This thesis describes studies that assisted the expanding and advancement of forensic RNA profiling assays used for the inference of body fluids and organ tissues.
Promotor: Supervisor: P. de Knijff Co-Supervisor: L.M.T. Sijen
Faculty: Medicine / Leiden University Medical Center (LUMC)
University: Leiden
Uri: urn:isbn:9789082749038
Handle: http://hdl.handle.net/1887/62865
 

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