Novel protecting group strategies in the synthesis of oligosaccharides

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Novel protecting group strategies in the synthesis of oligosaccharides

Type: Doctoral Thesis
Title: Novel protecting group strategies in the synthesis of oligosaccharides
Author: Volbeda, A.G.
Issue Date: 2018-05-31
Keywords: Carbohydrate synthesis
Protecting groups
Solid phase synthesis
Oligosaccharides
Abstract: The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups. New protecting group deprotection methods and protecting groups are developed. These novelties are applied in the synthesis of oligosaccharides which represent interesting biological targets. A solid phase approach is used to construct a library of oligorhamnans, employing a protecting group developed in this thesis. A fast deprotection method is employed to selectively remove fucntionalized benzyl ethers, which allows for the introduction of functional groups on a mannuronic acid molecule. Future synthesis campaigns are drafted combining the methods used in the previous chapters.
Promotor: Supervisor: Marel G.A. van der Co-Supervisor: Codée J.D.C.
Faculty: Science
University: Leiden
Uri: urn:isbn:9789462999763
Handle: http://hdl.handle.net/1887/62453
 

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