The use of light in cancer immunotherapy

Leiden Repository

The use of light in cancer immunotherapy

Type: Doctoral Thesis
Title: The use of light in cancer immunotherapy
Author: Kleinovink, E.W.J.
Issue Date: 2018-04-19
Keywords: Cancer
Immunotherapy
T cells
PDT
Photodynamic
Imaging
Bioluminescence
Fluorescence
Abstract: The breakthrough of immunotherapy for cancer has introduced promising new options, but nonetheless only a minority of cancer patients show significant clinical benefit. This situation has inspired two avenues of research to find solutions to this problem: mechanistic studies to decipher the working mechanisms of immunotherapies and to investigate why many patients do not respond, and studies developing combination treatments to achieve clinical benefit in situations where immunotherapy alone is not sufficient. This thesis explores both these avenues by investigating applications of visible light in immunotherapy of cancer in pre-clinical models. We developed optical imaging platforms for visualization of immune cells and immunotherapies, which can shed light on the immunological events after administration of immunotherapy. In addition, we investigated novel therapies based on the combination of tumor ablation by Photodynamic Therapy and different types of immunotherapy. Our findings may prove useful in understanding success and failure of immunotherapy, and provide new combination treatment options when the efficacy of monotherapy is insufficient.
Promotor: Supervisor: Ossendorp F.A., Löwik C.W.G.M. Co-Supervisor: Herbert-Fransen M.F.
Faculty: Medicine / Leiden University Medical Center (LUMC)
University: Leiden
Uri: urn:isbn:9789461828828
Handle: http://hdl.handle.net/1887/61631
 

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application/pdf Cover 58.87Kb View/Open
application/pdf Title Page_Contents 161.4Kb View/Open
application/pdf Chapter 01 399.9Kb View/Open
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application/pdf Chapter 04 898.0Kb Under embargo until 2019-10-19
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application/pdf Chapter 06 2.136Mb Under embargo until 2019-10-19
application/pdf Chapter 07 217.4Kb View/Open
application/pdf Appendices 228.8Kb View/Open
application/pdf Summary_in Dutch 181.2Kb View/Open
application/pdf Propositions 125.8Kb View/Open

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