On the relation between genetic variation and osteoarthritis

Leiden Repository

On the relation between genetic variation and osteoarthritis

Type: Doctoral Thesis
Title: On the relation between genetic variation and osteoarthritis
Author: Hollander, W. den
Issue Date: 2018-03-29
Keywords: Osteoarthritis
Epigenomics
Transcriptomics
Genomics
Bioinformatics
DIO2
CRLF1
MGP
Abstract: In dit proefschrift worden de moleculaire mechanismen behandeld die onderliggend zijn aan artrose. Specifiek wordt genoomwijd onderzocht welke genen anders tot expressie komen in aangedaan vergeleken met gezond kraakbeen van artrose patienten. Dit in de context van epigenetische regulatie van gen expressie, specifiek door DNA methylatie in het licht van de lokale genetische context in de vorm van puntmutaties.
Promotor: Supervisor: Meulenbelt I., Slagboom P.E. Co-Supervisor: Ramos Y.F.M.
Faculty: Medicine / Leiden University Medical Center (LUMC)
University: Leiden
Uri: urn:isbn:9789462339224
Handle: http://hdl.handle.net/1887/60908
 

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application/pdf Title Page_Contents 212.1Kb View/Open
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application/pdf Chapter 02 1.304Mb View/Open
application/pdf Chapter 03 2.105Mb View/Open Full text at publisher site
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application/pdf Chapter 08_General discussion 272.6Kb View/Open
application/pdf Chapter 09_Summary in Dutch 187.8Kb View/Open
application/pdf Acknowledgements_CV_Publications 215.2Kb View/Open
application/pdf Propositions 678.3Kb View/Open

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