Quantitative MR in dystrophic muscle : It's more than fat

Leiden Repository

Quantitative MR in dystrophic muscle : It's more than fat

Type: Doctoral Thesis
Title: Quantitative MR in dystrophic muscle : It's more than fat
Author: Hooijmans, M.T.
Issue Date: 2017-12-13
Keywords: Quantitative MR
Skeletal Muscle
Duchenne Muscular Dystrophy
Muscular Dystrophies
Spatially localized 31P spectroscopie
Muscle disease
Diffusion Tensor imaging, MR confounders
Abstract: The overall aim of this thesis was to combine various quantitative MR measurements and compare these combined measurements between Duchenne Muscular Dystrophy (DMD) patients and healthy age-matched controls both on a cross-sectional and longitudinal level, in order to generate a better understanding of the underlying pathophysiology of the disease and ideally to determine the potential of these MRI outcome parameters for monitoring muscle tissue changes in a clinical setting. In order to achieve this aim, we assessed the effect of spatial localization, data quality and confounding effects on the quantification process for various MR outcome parameters. We found that, sufficient SNR is a prerequisite for reliable MR measurements. In addition, we found that út and water T2 changes need to be monitored in DTI in skeletal muscle. Second, we used a combination of quantitative MRI and spatially resolved 31P MRS to contribute to the understanding of the pathophysiology in DMD. We found that PDE-levels and water T2 changes occurred prior to the replacement of muscle tissue by fat. Subsequently, we found that PDE-levels had the potential to function as a marker to monitor muscle tissue changes in DMD
Promotor: Supervisor: Webb A.G. Co-Supervisor: Kan H.E., Niks E.H.
Faculty: Medicine / Leiden University Medical Center (LUMC)
University: Leiden
Uri: urn:isbn:9789492801159
Handle: http://hdl.handle.net/1887/59497
 

Files in this item

Description Size View
application/pdf Full Text 1.748Mb View/Open
application/pdf Cover 154.0Kb View/Open
application/pdf Title Page_Contents 100.3Kb View/Open
application/pdf Chapter 01 537.9Kb View/Open
application/pdf Chapter 02 349.6Kb View/Open Full text at publisher site
application/pdf Chapter 03 267.7Kb View/Open
application/pdf Chapter 04 325.7Kb View/Open Full text at publisher site
application/pdf Chapter 05 423.6Kb View/Open Full text at publisher site
application/pdf Chapter 06 364.6Kb View/Open Full text at publisher site
application/pdf Chapter 07_Summary 179.3Kb View/Open
application/pdf Chapter 08_Summary in Dutch 89.89Kb View/Open
application/pdf Publications_CV_Acknowledgements 120.3Kb View/Open
application/pdf Propositions 91.99Kb View/Open

This item appears in the following Collection(s)