Prevalence, symptoms and risk profiles of apathy at old age

Leiden Repository

Prevalence, symptoms and risk profiles of apathy at old age

Type: Doctoral Thesis
Title: Prevalence, symptoms and risk profiles of apathy at old age
Author: Koolhoven, I.
Issue Date: 2017-11-07
Keywords: Apathy
Amotivation
Old age
Latent Class analysis
Subtypes of apathy
Apathy Scale
Depression
Quality of life
Cognition
Early- and late-life
Abstract: This thesis investigates different aspects of apathy - as a distinct clinical syndrome assessed with the Apathy Scale- in older persons with and without concurrent depression. In Chapter 2, clinically relevant subtypes of apathy according to the Apathy Scale in older persons from the PROMODE study are examined, using data-driven Latent Class Analysis (LCA). Further, specific characteristics across the classes identified by LCA are investigated. Then, in Chapter 3, cross-sectionally the prevalence, severity and clinical profile of apathy in depressed and non-depressed older persons, in relation to various possible determinants is described. Chapter 4 examines which characteristics predict, over a 2-year period, the incidence and course of apathy in at baseline depressed older persons from the NESDO study. Chapter 5, using data of the NESDO and NESDA, investigates the presence of  apathy in late-life compared to early-life depression, and various determinants of clinically relevant apathy in older compared to younger depressed persons. In Chapter 6 the association of the presence of apathy among community-dwelling older persons from the PROMODE study and a diminished quality of life is examined. All results are placed a current perspective in Chapter 7 that also discusses clinical implications, and makes some recommendations for future research.
Promotor: Supervisor: Mast R.C. van der Co-Supervisor: Comijs H.C., Naarding P.
Faculty: Medicine / Leiden University Medical Center (LUMC)
University: Leiden
Uri: urn:isbn:9789077877210
Handle: http://hdl.handle.net/1887/59456
 

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