Caging ruthenium complexes with non-toxic ligands for photoactivated chemotherapy

Leiden Repository

Caging ruthenium complexes with non-toxic ligands for photoactivated chemotherapy

Type: Doctoral Thesis
Title: Caging ruthenium complexes with non-toxic ligands for photoactivated chemotherapy
Author: Cuello Garibo, J.A.
Issue Date: 2017-12-19
Keywords: Photochemistry
Ruthenium
Photoactivated chemotherapy
Metallodrugs
Photopharmacology
Coordination Chemistry
Cancer
Abstract: The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand. We first investigated whether non-toxic ligands such as L-proline, 2-(methylthio)methylpyridine (mtmp), or 3-(methylthio)propylamine (mtpa), once coordinated to ruthenium(II) complexes, could be photosubstituted upon visible light irradiation. The lipophilicity, and in some cases the strain of the ruthenium(II) complexes, were systematically varied and the effects of such variations on the cytotoxicity of the complexes in the dark and under light irradiation were studied. In the second part, the best ligand candidates (i.e. mtmp and mtpa) were coordinated to cyclometalated ruthenium complexes of the type [Ru(bpy)(phpy)(S,N)]PF6 (bpy = 2,2’-bipyridine and phpy = 2-phenylpyridine), to shift the absorption of the complex to the red region of the spectrum. The photosubstitution properties of these cyclometallated complexes were investigated in detail. The most promising ruthenium complexes were tested in cancer cell monolayers under hypoxic conditions (1% O2) to investigate their mode of action and distinguish between PACT and PDT.
Promotor: Supervisor: Bouwman E. Co-Supervisor: Bonnet S.
Faculty: Science
University: Leiden
Uri: urn:isbn:9789462997967
Handle: http://hdl.handle.net/1887/58688
 

Files in this item

Description Size View
application/pdf Full Text 11.25Mb Under embargo until 2019-06-19
application/pdf Cover 6.813Mb View/Open
application/pdf Title Pages_Contents 176.2Kb View/Open
application/pdf Chapter 1 413.1Kb View/Open
application/pdf Chapter 2 1.429Mb View/Open Full text at publisher site
application/pdf Chapter 3 624.7Kb View/Open Full text at publisher site
application/pdf Chapter 4 1.773Mb Under embargo until 2019-06-19 Full text at publisher site
application/pdf Chapter 5 1.127Mb Under embargo until 2019-06-19
application/pdf Chapter 6 565.8Kb View/Open
application/pdf Chapter 7 381.0Kb View/Open
application/pdf Appendices 6.724Mb View/Open
application/pdf Summary in Dutch 246.0Kb View/Open
application/pdf Publications_Curriculum Vitae_Acknowledgements 197.7Kb View/Open
application/pdf Propositions 144.0Kb View/Open

This item appears in the following Collection(s)