Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo

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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo

Type: Doctoral Thesis
Title: Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Author: Witte, W.E.A. de
Issue Date: 2017-12-19
Keywords: Binding kinetics
Dissociation rate constant
PKPD
Modeling
Rate-limiting ste
Discovery
Abstract: Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction. However, the time course of a drug effect is also influenced by many other physiological processes such as the metabolism and excretion of a drug and the transduction of the relevant biological signals. In this study, we investigate when target binding kinetics are determining the time course of drug effect and generate understanding into the relation between the parameter values and the rate-limiting step in the duration of a drug effect.
Promotor: Supervisor: Danhof M., Graaf P.H. van der Co-Supervisor: Lange E.C.M. de
Faculty: Science
University: Leiden
Uri: urn:isbn:9789463322782
Handle: http://hdl.handle.net/1887/58472
 

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