Tracking helminths : from molecular diagnostics to mechanisms behind immune polarization

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Tracking helminths : from molecular diagnostics to mechanisms behind immune polarization

Type: Doctoral Thesis
Title: Tracking helminths : from molecular diagnostics to mechanisms behind immune polarization
Author: Kaisar, M.M.
Issue Date: 2017-09-19
Keywords: Indonesia
Real-time PCR
Helminths
Dendritic cells
T cells
Proteomics
Lipidomics
Abstract: Parasitic helminths are important organisms to study because their infections have both adverse and beneficial effects on the human host. Helminth infections are considered a burden, as these infections cause significant morbidity in a large proportion worldwide. However, helminth infections, by means of their ability to modify host immune responses can also provide protection against inflammatory diseases (inflammatory bowel disease, diabetes, and asthma). It is important to better understand the underlying mechanisms of these Yin (positive) and Yang (negative) consequences of helminth infections. The general objective of this thesis is to track helminths at different levels. On the one hand to improve the detection of helminth infections, essential for the studying helminths and the interaction with their human host. Moreover, a more sensitive diagnostics is instrumental for monitoring the distribution of helminth infections and to evaluate the helminth infections elimination program. On the other hand, to understand the mechanistic insights of the interplay between helminths and the host immune system results in priming of Th2 and regulatory T cell responses. This could contribute to the identification of targeted pathways to manipulate immune responses, as part of developing therapeutics to treat inflammatory disorders characterized by deregulated Th2 and/or Treg responses. 
Promotor: Supervisor: Yazdanbakhsh M. Co-Supervisor: Everts B.
Faculty: Faculty of Medicine, Leiden University Medical Center (LUMC)
University: Leiden
Uri: urn:isbn:9789461828262
Handle: http://hdl.handle.net/1887/57928
 

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application/pdf List of Publications 112.5Kb View/Open
application/pdf Acknowledgements 135.3Kb View/Open
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