Catecholamine function, brain state dynamics, and human cognition

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Catecholamine function, brain state dynamics, and human cognition

Type: Doctoral Thesis
Title: Catecholamine function, brain state dynamics, and human cognition
Author: Van den Brink R.L.
Issue Date: 2017-11-07
Keywords: Neuromodulation
Norepinephrine
Dopamine
Connectivity
Cognition
Attention
Abstract: The locus coeruleus (LC) is a nucleus in the brainstem, and projects widely to the forebrain where it releases norepinephrine (NE). Catecholamines such as NE do not have a unitary effect on their target neurons, but instead influence the function of other neurotransmitters, a process that is known known as neuromodulation. By virtue of the LC’s wide projection profile and the neuromodulatory properties of NE, the LC-NE system profoundly influences neural firing characteristics and associated cognitive processes. The work presented in this thesis addresses the role of the LC-NE system in various aspects of human cognition, and the modulation of brain state.
Promotor: Supervisor: NIeuwenhuis S.T. Co-Supervisor: Steenbergen H. van
Faculty: Social and Behavioural Sciences
University: Leiden
Uri: urn:isbn:9789402807592
Handle: http://hdl.handle.net/1887/54947
 

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