Toward selective anticancer metallodrugs

Leiden Repository

Toward selective anticancer metallodrugs

Type: Doctoral Thesis
Title: Toward selective anticancer metallodrugs
Author: Rixel, V.H.S. van
Issue Date: 2017-10-19
Keywords: Chemotherapy
Platinum
Palladium
Ruthenium
Photo activated chemotherapy
Photopharmacology
Metallodrugs
Cancer
Abstract: The field of transition-metal based chemotherapeutics are dominated by derivatives of cisplatin, but a major downside of these platinum based chemotherapeutics is their lack of selectivity that leads to undesirable side effects. In this work we present alternative strategies such as light-activation with different transition-metals such as ruthenium and palladium that have the potential to be more selective than cisplatin type of drugs.
Promotor: Supervisor: Bouwman E. Co-Supervisor: Bonnet S.
Faculty: Science
University: Leiden
Handle: http://hdl.handle.net/1887/54935
 

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application/pdf Appendices 5.653Mb Under embargo until 2018-04-19
application/pdf Summary in Dutch 693.2Kb Under embargo until 2018-04-19
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