Obesity and type 2 diabetes : cardiovascular and cerebral aspects

Leiden Repository

Obesity and type 2 diabetes : cardiovascular and cerebral aspects

Type: Doctoral Thesis
Title: Obesity and type 2 diabetes : cardiovascular and cerebral aspects
Author: Widya, R.L.
Issue Date: 2017-09-05
Keywords: Obesity
Diabetes
NAFLD
MRI
Spectroscopy
Aorta
Diastolic function
Brain
fMRI
Abstract: The prevalence of obesity, defined as a body mass index (BMI) > 30 kg/m2, is increasing to epidemic proportions. In 2014, 11% of men and 15% of women worldwide were obese. Thus, more than half a billion adults worldwide are classed as obese. The fundamental cause of obesity is an imbalance between energy intake (excessive intake of energy-dense foods) and energy expenditure (reduced physical activity). People with obesity are at risk for a range of chronic conditions including cardiovascular disease (CVD) and nonalcoholic fatty liver disease (NAFLD). Furthermore, obesity is a major risk factor for the development of type 2 diabetes, which is one of the most common chronic diseases in nearly all countries. According to the World Health Organization, the global prevalence of diabetes in 2014 was estimated to be 9%, of which 90% was comprised of type 2 diabetes. This thesis focuses on cardiovascular and cerebral dimensions and function in people with obesity and type 2 diabetes. State-of-the-art imaging techniques are used to investigate links between the heart, liver, abdominal fat, and brain to elucidate parts of the complex relationships between these organs.  
Promotor: Supervisors: H.J. Lamb; A. de Roos; J.W.A. Smit
Faculty: Medicine
University: Leiden
Uri: urn:isbn:9789492683755
Handle: http://hdl.handle.net/1887/54684
 

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application/pdf Chapter 1 General introduction 2.346Mb View/Open
application/pdf Part I Cardiovascular system 737.0Kb View/Open
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application/pdf Part 2 Brain 743.6Kb View/Open
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application/pdf Chapter 10 Summary_Summary in Dutch 758.7Kb View/Open
application/pdf Acknowledgement ... lications_Curriculum Vitae 734.8Kb View/Open
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