The role of PTHrP in chondrocyte differentiation

Leiden Repository

The role of PTHrP in chondrocyte differentiation

Type: Doctoral Thesis
Title: The role of PTHrP in chondrocyte differentiation
Author: Hoogendam, Jakomijn
Publisher: Department Pediatrics, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2006-12-06
Keywords: ATDC5 cell line
BOCD
cDNA microarray
Chondrocytes
Growth plate
Nherf
PTHR1
PTHrP
qPCR
Abstract: Longitudinal growth is the key characteristic that distinguishes children from adults. Growth is regulated in the growth plates, which are layers of cartilage located at the ends of the long bones. The cartilage cells are called chondrocytes and go through a coordinated program of proliferation, maturation, hypertrophic differentiation, apoptosis and replacement by bone. This process is called endochondral bone formation. A complex network of hormones (endocrine regulators) is involved in this process. The mechanism of actions of these hormones is not completely understood. A possible mechanism of action is the interaction of systemic hormones with locally produced growth factors (paracrine regulators), like the Parathyroid Hormone (PTH) related Peptide (PTHrP) and its receptor, the type 1 PTH/PTHrP receptor (PTHR1). PTHrP and PTHR1 are among the key regulators in the process of endochondral bone formation. The working mechanism of PTHrP signalling, alone or in combination with other growth factors or systemic hormones, in endochondral bone formation is not completely understood. In this thesis, we have further addressed the actions of PTHrP in the complex network of endocrine and paracrine regulation of endochondral bone formation.
Description: Promotor: J.M. Wit, Co-promotor: M. Karperien
With summary in Dutch
Faculty: LUMC
Citation: Hoogendam, J., 2006, Doctoral thesis, Leiden University
ISBN: 9789064640285
9064640289
Sponsor: Netherlands Organization of Scientific Research (NWO), department of Paediatrics of the LUMC, Nederlandse Vereniging van Calcium en Botstofwisseling (NVCB)
Handle: http://hdl.handle.net/1887/5422
 

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