The role of ApoCI, LPL and CETP in plasma lipoprotein metabolism - studies in mice

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The role of ApoCI, LPL and CETP in plasma lipoprotein metabolism - studies in mice

Type: Doctoral Thesis
Title: The role of ApoCI, LPL and CETP in plasma lipoprotein metabolism - studies in mice
Author: Hoogt, Cornelia Catharina van der
Publisher: Faculty of Medicine, Leiden University Medical Center, Leiden University
Issue Date: 2006-11-28
Keywords: Lipoproteins
Reverse cholesterol transport
HDL metabolism
VLDL metabolism
Abstract: This thesis contributes to a better understanding of the roles of apoCI, LPL, and CETP in lipoprotein metabolism. Our data illustrate that the activity of LPL, and thereby the level of plasma TG, is crucially determined by the relative abundance of apolipoproteins. In addition, we showed that LPL is an important determinant in remnant-particle clearance in the absence of the three main apoE-recognizing receptors. Finally, we demonstrated that CETP presents a pro-atherogenic factor in mice resembling a human lipid distribution over lipoproteins and that atorvastatin and fenofibrate treatment influence HDL-metabolism via inhibition of CETP, which may thus add to their therapeutic benefit. Since there were initial concerns that inhibition of CETP would reduce the flux of cholesteryl esters from the periphery back to the liver, thereby possibly increasing the risk for atherosclerosis, it is of interest that we found that fenofibrate-mediated inhibition of CETP did not hamper the total flux of HDL-cholesteryl esters. This holds promise for therapies based on CETP inhibition.
Description: Promotor: L.M. Havekes, Co-promotor: P.C.N. Rensen
With Summary in Dutch
Faculty: LUMC
Citation: Hoogt, C.C. van der, 2006, Doctoral Thesis, Leiden University
ISBN: 9090208585
Sponsor: The studies described in this thesis were supported by a grant from the Netherlands Organization of Scientific Research (NWO/ZonMW 908-02-097). The studies were performed at the Gaubius Laboratories of TNO-Quality of Life and the Leiden University Medical Center, the Netherlands

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application/pdf Propositions 40.24Kb View/Open
application/pdf Curriculum vitae 27.80Kb View/Open
application/pdf List of Publications 40.45Kb View/Open
application/pdf Abbreviations 32.00Kb View/Open
application/pdf Summary in Dutch 42.63Kb View/Open
application/pdf Summary in English 42.89Kb View/Open
application/pdf Chapter 9 128.9Kb View/Open
application/pdf Chapter 8 136.2Kb View/Open
application/pdf Chapter 7 223.9Kb View/Open
application/pdf Chapter 6 483.0Kb View/Open
application/pdf Chapter 5 87.68Kb View/Open
application/pdf Chapter 4 273.2Kb View/Open
application/pdf Chapter 3 147.3Kb View/Open
application/pdf Chapter 2 189.1Kb View/Open
application/pdf Chapter 1 194.8Kb View/Open
application/pdf Title page_Contents 45.72Kb View/Open
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