Signalling pathways that control development and antibiotic production in streptomyces

Leiden Repository

Signalling pathways that control development and antibiotic production in streptomyces

Type: Doctoral Thesis
Title: Signalling pathways that control development and antibiotic production in streptomyces
Author: Urem, M.
Issue Date: 2017-10-10
Keywords: Aminosugar metabolism
N-acetylglucosamine
Glucosamine
Regulation
Metabolism
Suppressor mutants
Stress
Two-component systems
ROK-family regulators
Metabolic enzymes
Abstract: Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments. Actinobacteria, with their beautiful morphologies and complex multicellular life cycle, are a striking example. These filamentous bacteria produce many enzymes and natural products, including two-thirds of all known antibiotics, which makes them highly relevant for medical, biotechnological and industrial applications. In Streptomyces, complex and intertwining regulatory networks, consisting of pathway-specific and global regulators, control development and antibiotic production in response to environmental stimuli and stresses. This thesis explores how the model organism Streptomyces coelicolor senses environmental signals, related to oxygen stress and the availability of aminosugars, and how the bacterium translates these into appropriate responses.
Promotor: Supervisor: Wezel G.P. van
Faculty: Science
University: Leiden
Handle: http://hdl.handle.net/1887/53237
 

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