Greased lighting : implications of circadian lipid metabolism for cardiometabolic health

Leiden Repository

Greased lighting : implications of circadian lipid metabolism for cardiometabolic health

Type: Doctoral Thesis
Title: Greased lighting : implications of circadian lipid metabolism for cardiometabolic health
Author: Berg, R. van den
Issue Date: 2017-10-12
Keywords: Circadian
Rhythm
Lipid
Cardiovascular disease
Metabolism
Biological clock
Adipose tissue
Abstract: Cardiovascular diseases (CVD) are the leading cause of death worldwide, and disturbances in day-night rhythms have recently been implicated as a novel risk factor for CVD. We investigated the effects of modulating circadian rhythms on energy metabolism using animal models and by studying plasma metaoblites and lipids in humans. Using animal studies we observed that brown adipose tissue (BAT) is strongly regulated by the biological clock, possibly via circadian glucocorticoid rhythms, and attenuated BAT activity through prolonged light exposure increases adiposity. Research focusing on the rhythm in human BAT, and regulation thereof, is necessary to confirm the translational value of our findings. We also observed that mistimed light exposure enhances atherosclerosis development, which may provide a mechanistic link between the known association between shift work and CVD. We anticipate that living according to the natural circadian rhythms presumably contributes to cardiometabolic health. Since disturbances in day-night rhythms are inevitable in modern society, in the future we may advise individuals at risk for development of CVD refrain from shift work and short sleep duration. In addition, data in this thesis may be useful to design strategies to avoid the disadvantageous metabolic effects of shift work.
Promotor: Supervisor: Rensen P.C.N. Co-Supervisor: Biermasz N.R.
Faculty: Faculty of Medicine, Leiden University Medical Center (LUMC)
University: Leiden
Uri: urn:isbn:9789088905421
Handle: http://hdl.handle.net/1887/53234
 

Files in this item

Description Size View
application/pdf Propositions 65.13Kb Under embargo

This item appears in the following Collection(s)