Structural changes of chromatin fibers induced by variation of linker DNA length

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Structural changes of chromatin fibers induced by variation of linker DNA length

Type: Master thesis
Title: Structural changes of chromatin fibers induced by variation of linker DNA length
Author: Botto, Margherita
Issue Date: 2017-10
Keywords: chromatin, nucleosomes, DNA
Abstract: In this thesis we are going to study the mechanical properties of a chromatin fiber. Chromatin is the second compaction stage of DNA, after the wrapping of DNA around histones proteins to form nucleosomes. Specifically we are going to analyze how its behaviour under external stresses is going to change with the variation of the linker DNA length, the DNA segment that links two adjacent nucleosomes. We will be able to do it at a single-molecule level thanks to the use of magnetic tweezers, an apparatus that can exert forces and torques directly to individual molecules.
Supervisor: van Noort, John
Faculty: Faculty of Science
Department: Physics (Master)
Specialisation: Experimental Physics
ECTS Credits: 5
Handle: http://hdl.handle.net/1887/53213
 

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