The effect of curvature on diffusion in solid supported lipid bilayers

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The effect of curvature on diffusion in solid supported lipid bilayers

Type: Bachelor thesis
Title: The effect of curvature on diffusion in solid supported lipid bilayers
Author: Haaf, Bas ten
Issue Date: 2017-07-31
Keywords: Solid supported lipid bilayer
Curvature influenced diffusion
Membrane protein
Colloidal particles
Abstract: Theoretical models have shown that the geometry of cell membranes affects the diffusion rate of both proteins and lipids in the cell membrane. In this thesis we present a setup that has been developed to study two different diffusion effects. The first is the effect of curvature on a field of lipids and the second is the effect of curvature on diffusing colloidal particles. The setup consists of microsized 3D printed structures characterized by different curvatures combined with colloidal particles DNA linked to the structures. Quantitative data has been collected on the motion of the lipids in spherically curved bilayers on the structures, as well as qualitative data on the mobility of different colloids. The setup has been developed to the point that it can soon be used for collecting quantitative data on the colloidal motion.
Supervisor: Kraft, DanielaRinaldin, Melissa
Faculty: Faculty of Science
Department: Physics (Bachelor)
ECTS Credits: 3
Handle: http://hdl.handle.net/1887/50827
 

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