Persistent URL of this record https://hdl.handle.net/1887/50091
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- Title page_Table of contents
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- Chapter 1 General introduction
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- Chapter 2
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- Chapter 3
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- Chapter 4
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- Chapter 5
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- Chapter 8 Summary and general discussion
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- Propositions
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T cell immunity against MHC-Ilow tumors in mouse models
Tumors can evade recognition by the immune system through downregulation of the peptide-presenting MHC-I molecules. In this thesis, we describe that these tumors can still be targeted by a novel category of CD8 T cells, recognizing a specific peptide presented on those immune-escaped tumors. We describe the selection and characteristics of these specific T cells and show they can protect against a challenge with these MHC-I low tumors. This could be a novel type of therapy for tumors which have become resistant against conventional (immune)therapies.
- All authors
- Doorduijn, E.M.
- Supervisor
- Burg, S.H. van der
- Co-supervisor
- Hall, T. van
- Committee
- Koning, F.; Gruijl, T.D. de; Kuball, J.H.E.
- Qualification
- Doctor (dr.)
- Awarding Institution
- Medicine , Leiden University
- Date
- 2017-06-29
- ISBN
- 9789402806434