Helminth infections, allergic disorders and immune responses: studies in Indonesia

Leiden Repository

Helminth infections, allergic disorders and immune responses: studies in Indonesia

Type: Doctoral Thesis
Title: Helminth infections, allergic disorders and immune responses: studies in Indonesia
Author: Wahyuni, Sitti
Publisher: Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University
Issue Date: 2006-11-22
Keywords: Allergy
Abstract: The studies present in this thesis fall into two broad areas: the first focusing on filarial infection, Ig (immunoglobulin)E levels and risk factors for infection, while the second deals with the possible associations between nematode infection and allergy. Compared to ELISA, RAST is superior in detecting filarial specific IgE in endemic area of Brugia malayi. Levels of filaria-specific IgE and IgG4 in children up to 10 years correlated with maternal antibody levels. Genetic factors had a more pronounced effect in children than in adults. The use of objective measurements, such as skin prick test (SPT) and IgE levels are required when conducting epidemiological studies of allergic diseases in Indonesia. Study on risk factors of allergy in Indonesia showed that nutritional status of children in the high socioeconomic school negatively associate with SPT and IgE positivity but we did not show a statistically significant role for helminths in inhibiting SPT responses. In endemic area of lymphatic filariasis, genetic factors contribute significantly to both total and allergen-specific IgE, whereas environmental factors influence the clustering of SPT positivity. By using several TLR ligands it was demonstrated that the dynamics of cytokine production following the innate immune stimulation can differ according to helminth infection status.
Description: Promotores: A.M. Deelder, D.M. Yazdanbakhsh, Co-promotor: J.J. Houwing-Duistermaat
With summary in Dutch
Faculty: LUMC
Citation: Wahyuni, S., 2006, Doctoral thesis, Leiden University
ISBN: 9791527801
Sponsor: The Netherlands Foundation for the Advancement of Tropical Research (W93-325); Netherlands Organization for International Cooperation in Higher Education (NUFFIC); Van Deventer-Maas Stichting; European Commission, INCO programme, contract no: ICA4-CT-2001-10081; GLOFAL project FP6-2003-FOOD-2-B; Indonesia Embassy in the Netherlands, and Pembinaan Iptek Kedokteran 2005, Litbangkes, Indonesia.
Handle: http://hdl.handle.net/1887/4986

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application/pdf References 158.1Kb View/Open
application/pdf Summary 39.36Kb View/Open
application/pdf Summary in Dutch 44.08Kb View/Open
application/pdf Acknowledgements 26.06Kb View/Open
application/pdf Curriculum Vitae 22.7Kb View/Open
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