The palaeoproteomic identification of pleistocene hominin skeletal remains

Leiden Repository

The palaeoproteomic identification of pleistocene hominin skeletal remains

Type: Doctoral Thesis
Title: The palaeoproteomic identification of pleistocene hominin skeletal remains
Author: Welker, F.
Issue Date: 2017-05-18
Keywords: Ancient proteins
Palaeoproteomics
ZooMS
Collagen
Proteomics
Châtelperronian
Neanderthals
Modern Humans
Abstract: The Middle to Upper Palaeolithic transition in Europe witnesses the local replacement of Neanderthals by Anatomically Modern Humans. During this period several “transitional” technocomplexes are present that seem to combine behavioural characteristics from both the preceding Middle and following Upper Palaeolithic. These technocomplexes therefore play a critical role in our understanding of Neanderthal behavior, cognition and extinction, the dispersal of AMHs into Europe, and the interactions between Neanderthals and AMHs. Unfortunately, biological remains of the hominins responsible for the transitional technocomplexes are notoriously scarce. This dissertation proposes to utilize recent advances in mass spectrometry to identify additional hominin specimens through ZooMS screening and shotgun proteomics. Novel approaches towards de novo/error-tolerant proteomic analysis in Pleistocene contexts were developed and tested, allowing phylogenetic analysis of ancient protein sequences from now-extinct Mammalian species and hominin populations. ZooMS screening is shown to be highly successful for all included Châtelperronian sites. The discovery of additional hominin specimens at one archaeological site allowed demonstrating that ancient protein sequences can be used to differentiate between hominin populations, in this case indicating a Neanderthal affiliation. As a result, palaeoproteomics now allows studying the evolutionary relationships between hominin individuals based on ancient protein sequences.
Promotor: Supervisor: J.-J. Hublin, M.J. Collins
Faculty: Archaeology
University: Leiden
Handle: http://hdl.handle.net/1887/49751
 

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application/pdf Title page_Contents 228.0Kb View/Open
application/pdf Chapter 1 739.5Kb View/Open
application/pdf Chapter 2 1.113Mb Under embargo until 2019-05-18 Full text at publisher site
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application/pdf Chapter 6_Discussion & Conclusion 766.9Kb View/Open
application/pdf Summary 259.2Kb View/Open
application/pdf Summary_in Dutch 261.3Kb View/Open
application/pdf Acknowledgements 226.6Kb View/Open
application/pdf Curriculum Vitae 218.8Kb View/Open
application/pdf Propositions 249.8Kb View/Open

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