Immune-based therapies in ovarian cancer

Leiden Repository

Immune-based therapies in ovarian cancer

Type: Doctoral Thesis
Title: Immune-based therapies in ovarian cancer
Author: Dijkgraaf, E.M.
Issue Date: 2017-06-13
Keywords: Ovarian cancer
Immunotherapy
Toxilizumab
Vaccination
p53
Tumor microenvironment
Abstract: The generally poor prognosis of patients with epithelial ovarian cancer patients treated with curative intent, calls for additional treatment modalities and possible success might lie in a combination of chemotherapy and immunotherapy. This thesis focuses on the interaction of chemotherapy with the immune system and describes new combined chemo-immunotherapy treatment strategies. This thesis has explored new strategies, immune-modulation of the IL-6 pathway and a vaccine against p53, to enhance immune surveillance and to disable tumour immune evasion in ovarian cancer patients. The future challenge for immunotherapy against ovarian cancer is a tailored combinatorial approach to test the rationale of potentially synergistic therapies that can induce efficient antitumour immunity and prolong patients’ survival.
Promotor: Supervisor: S.H. van der Burg, J.J.M. van der Hoeven Co-Supervisor: J.R. Kroep, M.J.P. Schoenmaekers-Welters
Faculty: Faculty of Medicine, Leiden University Medical Center (LUMC)
University: Leiden
Uri: urn:isbn:9789462995734
Handle: http://hdl.handle.net/1887/49549
 

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