Controlling human Oesophagostomiasis in Northern Ghana

Leiden Repository

Controlling human Oesophagostomiasis in Northern Ghana

Type: Doctoral Thesis
Title: Controlling human Oesophagostomiasis in Northern Ghana
Author: Ziem, J.B.
Issue Date: 2006-06-04
Keywords: Control
Lymphatic filariasis elimination programme
Stool cultures
Abstract: This thesis describes aspects of the epidemiology and attempts to control infection and pathology due to the nematode parasite Oesophagostomum bifurcum . In northern Ghana and Togo O. bifurcum is an important parasite of humans; elsewhere it is predominantly seen as a parasite of non-human primates. It is shown that frequency and severity of colonic pathology, measured by ultrasound, is associated with the intensity of infection as measured with coproculture. Females are more infected than males but convincing explanations for the gender-dependent difference of infection rates are not found. Details of the route of transmission remain obscure. Mass treatment with Albendazole resulted in a very important reduction of both prevalence and morbidity of infection. Elimination of human oesophagostomiasis is within reach. The impact on hookworms, also effectively killed by the drug, is considerably smaller. Interruption of Albendazole treatment results of rapidly increasing infection rates in hookworm but not in Oesophagostomum. Integration of control activities in the filariasis elimination programme is likely to result in elimination of human oesophagostomiasis but not of human hookworm infection.
Promotor: Supervisor: Deelder A.M. Co-Supervisor: Polderman A.M., Magnussen P.
Faculty: Faculty of Medicine, Leiden University Medical Center (LUMC)
University: Leiden University
Uri: urn:isbn:9789074384056

Files in this item

Description Size View
application/pdf Cover 204.6Kb View/Open
application/pdf Propositions 485.8Kb View/Open
application/pdf Title page_Contents 84.22Kb View/Open
application/pdf Chapter 1 2.552Mb View/Open
application/pdf Chapter 2 593.7Kb View/Open
application/pdf Chapter 3 229.8Kb View/Open
application/pdf Chapter 4 1.175Mb View/Open
application/pdf Chapter 5 199.4Kb View/Open Full text at publisher site
application/pdf Chapter 6 348.8Kb View/Open Full text at publisher site
application/pdf Chapter 7 308.6Kb View/Open
application/pdf Chapter 8 172.4Kb View/Open Full text at publisher site
application/pdf Chapter 9 152.9Kb View/Open
application/pdf References 150.7Kb View/Open
application/pdf Summary 103.9Kb View/Open
application/pdf Summary in French 108.3Kb View/Open
application/pdf Acknowledgements 62.85Kb View/Open
application/pdf Curriculum Vitae 57.88Kb View/Open
application/pdf Summary in Dutch 107.1Kb View/Open

This item appears in the following Collection(s)