Synthesis of well-defined ADP-Ribosylated biomolecules

Leiden Repository

Synthesis of well-defined ADP-Ribosylated biomolecules

Type: Doctoral Thesis
Title: Synthesis of well-defined ADP-Ribosylated biomolecules
Author: Kistemaker, H.A.V.
Issue Date: 2017-05-11
Keywords: poly-ADPr
PARP
ADP-ribose
Ribose
Pyrophosphate
Phosphorylation
Ribosylation
Glycosylation
MARylation
PARylation
Abstract: The post-translational modification of proteins known as adenosine diphosphate ribosylation (ADPr) is involved in a wide variety of important biological processes and is also associated with carcinogenesis and the process of aging. Therefore, a better understanding of the biology of ADP-ribosylation is crucial for the development of novel therapeutics. To facilitate this research, the availability of well-defined fragments of mono- and poly-ADP-ribose is essential. This Thesis describes the development of new synthetic methodologies to achieve this and the successful synthesis of well-defined ADP-ribosylated biomolecules.
Promotor: Supervisor: G. A. van der Marel Co-Supervisor: D. V. Filippov
Faculty: Science
University: Leiden
Uri: urn:isbn:9789462995901
Handle: http://hdl.handle.net/1887/49075
 

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