Unravelling narcolepsy : from pathophysiology to measuring treatment effects

Leiden Repository

Unravelling narcolepsy : from pathophysiology to measuring treatment effects

Type: Doctoral Thesis
Title: Unravelling narcolepsy : from pathophysiology to measuring treatment effects
Author: Heide, A. van der
Issue Date: 2017-05-24
Keywords: Narcolepsy
Autoimmune
Cataplexy
SART
Vigilance
Symptoms
Treatment
Abstract: Narcolepsy is a disorder of the regulation of sleep and wakefulness, with as its major features excessive daytime sleepiness (EDS), cataplexy, hypnagogic hallucinations, sleep paralysis and disturbed nocturnal sleep. The first part of this thesis concernes an overview of the pathophysiology, symptoms and treatment of narcolepsy type 1. The second part elaborates some pathophysiological aspects, focussing on the autoimmune hypothesis of narcolepsy. The third part focuses on alterations of temperature regulation and on measuring treatment effects of symptomatic treatment on sustained attention, i.e. vigilance.
Promotor: Supervisor: J.G. van Dijk Co-Supervisor: G.J. Lammers
Faculty: Faculty of Medicine, Leiden University Medical Center (LUMC)
University: Leiden
Uri: urn:isbn:9789490791551
Handle: http://hdl.handle.net/1887/49010
 

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