Targeted imaging in oncologic surgery : preclinical studies utilizing near-infrared fluorescence and radioactivity

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Targeted imaging in oncologic surgery : preclinical studies utilizing near-infrared fluorescence and radioactivity

Type: Doctoral Thesis
Title: Targeted imaging in oncologic surgery : preclinical studies utilizing near-infrared fluorescence and radioactivity
Author: Boonstra, M.C.
Issue Date: 2017-04-13
Keywords: Fluorescent-guided
Surgery
Intraoperative imaging
Multimodal
Tracer
Membrane-proteins
Near-infrared
Cancer
Real-time
Abstract: Fluorescence-guided surgery (FGS) is an intraoperative imaging technique already introduced and validated in the clinic for sentinel lymph node mapping and biliary imaging. Conjugating a NIR-dye to a specific tumor-targeting vehicle dramatically enhances the specificity of this technique. Hence, a powerful synergy can be achieved when fluorescent imaging is combined with nuclear imaging. The (NIR) fluorescent signal aids the surgeon to accurately recognize and resect malignant tissues and detect (nearby) vital structures in real-time during surgery, while its nuclear counterpart can be used to preoperative assess tumor spread and aid in the surgical planning and guidance. Patients may benefit directly from better tumor detection as the surgical status (R0 or R1) is one of the most import parameters for morbidity and patient survival. This thesis focus on the evaluation of potential targets for image-guided surgery applications and describes the preclinical evaluation of novel tracers for (hybrid) image-guided surgery.
Promotor: Supervisor: C.J.H. van de Velde Co-Supervisor: A.L. Vahrmeijer
Faculty: Medicine
University: Leiden
Uri: urn:isbn:9789492683076
Handle: http://hdl.handle.net/1887/47856
 

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