Persistent URL of this record https://hdl.handle.net/1887/46476
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- Title page_Contents
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- Chapter 2
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- Chapter 3
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- Chapter 8 General discussion and summary
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- General discussion and summary in Dutch
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Tissue factor isoforms and factor VII in cancer progression
This thesis describes the respective contribution of the expression of Tissue factor isoforms full length Tissue Factor (flTF) and alternatively spliced Tissue Factor (asTF) as well as Factor VII by tumor cells to promote cancer progression. Cohorts of breast, colon, and bone cancer specimens and a multitude of in vitro and in vivo models were used to explore the mechanism behind enhanced cell proliferation and metastasis in in vitro and in vivo models, as well as decreased patient survival associated with TF and FVII expression in cancer patients.
- All authors
- Tieken, C.
- Editor(s)
- Tieken C.
- Supervisor
- Versteeg, H.H.; Reitsma, P.H.
- Committee
- Zonneveld, A.J. van; Goumans, M.J.T.H.; Quax, P.H.A.; Cate, H. ten; Spek, C.A.
- Qualification
- Doctor (dr.)
- Awarding Institution
- Medicine , Leiden University
- Date
- 2017-03-09