Charting the dynamic methylome across the human lifespan

Leiden Repository

Charting the dynamic methylome across the human lifespan

Type: Doctoral Thesis
Title: Charting the dynamic methylome across the human lifespan
Author: Slieker, R.
Issue Date: 2017-02-09
Keywords: DNA methylation
Ageing
Development
Tissues
Abstract: In this thesis we aimed to get insight in how the methylome is established during development and subsequently degenerates during ageing using an integrative approach to the analysis of DNA methylation in conjunction with other levels of genomics data. The first two empirical chapters of this thesis describe the establishment and the maintenance of the epigenome during fetal development and in later life in multiple tissues. In the subsequent two chapters we investigated the loss of control over the methylome in blood and other tissues.
Promotor: Supervisor: P.E. Slagboom Co-Supervisor: B.T. Heijmans
Faculty: Medicine
University: Leiden
Uri: urn:isbn:9789462335103
Handle: http://hdl.handle.net/1887/45888
 

Files in this item

Description Size View
application/pdf Cover 1.323Mb View/Open
application/pdf Full text 85.47Mb View/Open
application/pdf Title page_Content 149.5Kb View/Open
application/pdf Chapter 1 Introduction 1.874Mb View/Open
application/pdf Chapter 2 983.4Kb View/Open Full text at publisher site
application/pdf Chapter 3 5.173Mb View/Open Full text at publisher site
application/pdf Chapter 4 24.45Mb View/Open Full text at publisher site
application/pdf Chapter 5 2.713Mb View/Open
application/pdf Chapter 6 General discussion 2.135Mb View/Open
application/pdf Chapter 7 Summary in Dutch 664.2Kb View/Open
application/pdf Acknowledgements_Curriculum Vitae_Publications 559.8Kb View/Open
application/pdf Chapter 9 Appendices 48.17Mb View/Open
application/pdf Propositions 91.46Kb View/Open

This item appears in the following Collection(s)