The stressed brain - discovering the neural pathways to risk and resilience

Leiden Repository

The stressed brain - discovering the neural pathways to risk and resilience

Type: Doctoral Thesis
Title: The stressed brain - discovering the neural pathways to risk and resilience
Author: Werff, S.J.A. van der
Issue Date: 2017-01-10
Keywords: Resilience
Stress
Hypercortisolism
Magnetic resonance imaging
Cushing's disease
Neuroimaging
Abstract: The human body is inherently designed to be able to adapt to challenging situations. However, some experiences are so severe that they can lead to substantial and longerlasting disturbances in an individuals’ behavioral, psychological and physiological functioning. Importantly, there is a degree of inter-individual variation, as not all individuals show similar reactions to severe stress. Neuroimaging techniques can help to unravel the brain characteristics related to vulnerability and resilience to severe stress. In the research for this dissertation several neuroimaging modalities were used to further explore the brain characteristics related to (dys)function after exposure to severe stress and after exposure to hypercortisolism, such as voxel-based morphometry and diffusion tensor imaging to study the structure of gray and white matter in the brain, and resting-state fMRI to study functional connectivity patterns. We studied brain characteristics in several groups consisting of: patients in long-term remission of Cushing’s disease, and individuals with a history of childhood emotional maltreatment to examine the effects of hypercortisolism and severe stress on the brain. In addition, we studied a group of police officers and a group of individuals with a history of childhood maltreatment to investigate the brain characteristics related to resilience to stress.
Promotor: Supervisor: N.J.A. van der Wee, B.M. Elzinga
Faculty: Medicine/ Leiden University Medical Center (LUMC)
University: Leiden
Uri: urn:isbn:9789463321099
Handle: http://hdl.handle.net/1887/45136
 

Files in this item

Description Size View
application/pdf Full Text 7.588Mb Under embargo until 2018-10-01
application/pdf Cover 394.0Kb View/Open
application/pdf Title Pages_Contents 744.5Kb View/Open
application/pdf Chapter 1 1.181Mb View/Open
application/pdf Chapter 2 1.939Mb View/Open Full text at publisher site
application/pdf Chapter 3 1.313Mb View/Open Full text at publisher site
application/pdf Chapter 4 2.030Mb View/Open Full text at publisher site
application/pdf Chapter 5 2.082Mb View/Open Full text at publisher site
application/pdf Chapter 6 1.306Mb View/Open Full text at publisher site
application/pdf Chapter 7 1.528Mb View/Open Full text at publisher site
application/pdf Chapter 8 1.601Mb View/Open
application/pdf Chapter 9 973.3Kb View/Open
application/pdf Summary in Dutch 694.8Kb View/Open
application/pdf Curriuculum VItae_Publications_Acknowledgements 743.4Kb View/Open
application/pdf Propositions 658.1Kb View/Open

This item appears in the following Collection(s)