Sensitivity study of diffusion-weighted MRI by comparing simulations to fiber phantom measurements

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Sensitivity study of diffusion-weighted MRI by comparing simulations to fiber phantom measurements

Type: Master thesis
Title: Sensitivity study of diffusion-weighted MRI by comparing simulations to fiber phantom measurements
Author: Verweij, R.W.
Issue Date: 2016-12-23
Keywords: MRI
diffusion
simulation
Abstract: Experimental diffusion-weighted MRI measurements of a fiber phantom were compared to signals generated using a Monte-Carlo diffusion simulation. The diffusion simulation was combined with a generally applicable MRI simulation. We performed simulations for square packed and random packed cylinders that model the fibers. Good agreement was found between the simulated signal and the measured signal for a specific random packing type (the relative error was 0.09+-0.06). Follow-up simulations that use larger system sizes are needed to improve the accuracy. The simulation method presented here can be used to study changes in microstructural properties and to compare the efficiency of different MRI protocols in detecting these changes.
Supervisor: Arkesteijn, JoorVos, FransVliet, Lucas vanOosterkamp, T.H.
Faculty: Faculty of Science
Department: Physics (Master)
Specialisation: Experimental Physics
ECTS Credits: 3
Handle: http://hdl.handle.net/1887/44947
 

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