The impact of obesity on the pharmacokinetics of drugs in adolescents and adults

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The impact of obesity on the pharmacokinetics of drugs in adolescents and adults

Type: Doctoral Thesis
Title: The impact of obesity on the pharmacokinetics of drugs in adolescents and adults
Author: Rongen, A. van
Issue Date: 2016-12-07
Keywords: Morbid obesity
Pharmacokinetics
Obese adolescents
Midazolam
Acetaminophen
Metformin
Abstract: Despite the increasing number of obese patients, evidence-based dosing guidelines are scarce, particularly for obese children and morbidly obese adults (BMI > 40 kg/m2). For both these populations, pharmacokinetic studies are needed to provide a basis for evidence-based dosing guidelines. In this thesis, we studied the pharmacokinetics of the CYP3A substrate midazolam, the renally excreted drug metformin and acetaminophen (metabolized by glucuronidation, sulphation and CYP2E1) in obese adolescents and/or morbidly obese adults. We address several currently unanswered questions; Can doses for obese adolescents be predicted on the basis of data obtained in morbidly obese adults? How to analyse pharmacokinetic data in obese adolescents, for whom body weight is influenced by growth, age and obesity? How to achieve safe and effective acetaminophen dosing for morbidly obese patients? The studies described in this thesis contribute to the existing gaps in knowledge regarding the pharmacokinetics and evidence-based dosing of drugs in obese adolescents and morbidly obese adults.
Promotor: Supervisors: C.A.J. Knibbe; J.N. van den Anker Co-Supervisors: H.P.A. van Dongen; B. van Ramshorst
Faculty: Science
University: Leiden
Uri: urn:isbn:9789461699428
Handle: http://hdl.handle.net/1887/44789
 

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application/pdf Section I 714.1Kb View/Open
application/pdf Chapter 1 Scope and intent of the investigations 767.9Kb View/Open
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application/pdf Chapter 9 2.973Mb Under embargo until 2018-06-07
application/pdf Section V 714.1Kb View/Open
application/pdf Chapter 10 Summary_conclusions and perspectives 1.238Mb View/Open
application/pdf Summary in Dutch 789.1Kb View/Open
application/pdf Curruclum Vitae ... _Epilogue_Acknowledgements 737.8Kb View/Open
application/pdf Propositions 580.7Kb View/Open

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