The serological gastric biopsy in primary care : studies on atrophic gastritis

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The serological gastric biopsy in primary care : studies on atrophic gastritis

Type: Doctoral Thesis
Title: The serological gastric biopsy in primary care : studies on atrophic gastritis
Author: Korstanje, Andries
Publisher: Dept. of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden University
Issue Date: 2006-06-26
Keywords: Pepsinogen
Helicobacter pylori
Gastric serum biopsy
Primary care
Abstract: This thesis sheds light on the clinical utility of serum markers of gastric atrophy, pepsinogen and gastrin, in general practice in the Dutch province of Zeeland. The biomarkers were used in studies on atrophic corpus gastritis, as surrogate outcome of gastric cancer. Attention was paid to seroepidemiological, aetiological and diagnostic aspects. Results of the thesis: - The seroprevalence of atrophic corpus gastritis in Zeeland appears to be 3.4%, which is higher than in other parts of the country (reference cohort studies, respectively 2.4% and 1.6%). The approximate relative risk of having corpus atrophy was higher(p<0.025) for antibodies to parietal cells(24) than to Helicobacter pylori (1.62). - The ¹³carbon urea breath test can be used as a reliable diagnostic H.pylori test in asymptomatic patients with atrophic corpus gastritis, preferably in addition to serology, to select subjects for anti-H.pylori therapy. - Proton pump inhibitor stimulated pepsinogen A might be useful to determine the severity of atrophic body gastritis and to identify patients with body atrophy in the case of borderline basal pepsinogen. The studies in this thesis have shed new light on some aspects of atrophic gastritis thanks to primary care research in an unselected, asymptomatic study population.
Description: Promotor: C.B.H.W. Lamers. Co-promotores I. Biemond, G. den Hartog.
With summary in Dutch.
Faculty: LUMC
Citation: Korstanje, A., 2006. Doctoral thesis, Leiden University
Sponsor: AstraZeneca BV

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